GeneID: 242


Common Name: KCNS1 Type: Gene
Chromosome: 20 (NC_000020.11) Locus: N/A
HUGO Symbol: KCNS1 Full Name: potassium voltage-gated channel modifier subfamily S member 1
Exons: 5 Introns: 4

This gene belongs to the S subfamily of the potassium channel family. Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. Voltage-gated potassium channels are formed by alpha and beta subunit tetramers. Alpha subunits belong to at least twelve families (Kv1-12). There are three Kv9 subunits (KCNS1, KCNS2, KCNS3), which are not functional by themselves but can modulate the activity of specific functional alpha subunits as heteromers. KCNS1 is implicated in the modulation of pain behaviour. A polymorphism in the KCNS1 gene has been associated with painful vaso-occlusive crisis episodes in sickle cell disease.

Synonyms: Kv9.1


Sequence Viewer

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Publications / Origin

  1. Shepard AR, Rae JL, Electrically silent potassium channel subunits from human lens epithelium., Am. J. Physiol. , 277(3), C412-24, 1999 PubMed
  2. Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, Wu T, Kiselycznyk C, Poddar M, Lu Y, Diatchenko L, Smith S, Cobos EJ, Zaykin D, Allchorne A, Gershon E, Livneh J, Shen PH, Nikolajsen L, Karppinen J, Männikkö M, Kelempisioti A, Goldman D, Maixner W, Geschwind DH, Max MB, Seltzer Z, Woolf CJ, Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1., Brain , 133(9), 2519-27, 2010 PubMed
  3. Wonkam A, Mnika K, Ngo Bitoungui VJ, Chetcha Chemegni B, Chimusa ER, Dandara C, Kengne AP, Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon., Br. J. Haematol. , 180(1), 134-146, 2018 PubMed
Created on 2018-01-31 18:51:20, Last reviewed on (Show full history)

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