GeneID: 220


Common Name: AVPR1A Type: Gene
Chromosome: 12 (NC_000012.12) Locus: N/A
HUGO Symbol: AVPR1A Full Name: arginine vasopressin receptor 1A
Exons: 2 Introns: 1

The protein encoded by this gene acts as receptor for arginine vasopressin (AVP). Also known as antidiuretic hormone (ADH), AVP is a small peptide of nine amino acids produced by the hypothalamus (primary site), mainly in response to changes in serum osmolality. It acts both locally and systemically through its receptors, which are located in the brain as well as in the periphery. These include AVPR1A, AVPR1B and V2R, and belong to the subfamily of G-protein coupled receptors. AVPR1A is present in various types of cells, including neuronal cells and the smooth muscle cells of vessels, and its activity is mediated by G proteins, which stimulate a phosphatidylinositol-calcium second messenger system. AVPR1A mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. AVP is involved in pain perception via the central nervous system through the AVPR1A and AVPR1B receptors. A polymoprhism in the AVPR1A gene associated with acute pain in sickle cell disease.

Synonyms: V1aR , AVPR1 , AVPR , V1a


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Publications / Origin

  1. Mavani GP, DeVita MV, Michelis MF, A review of the nonpressor and nonantidiuretic actions of the hormone vasopressin., Front Med (Lausanne) , 2(0), 19, 2015 PubMed
  2. Roach K, Jhun E, He Y, Suarez M, Yao Y, Molokie R, Wang Z, Wilkie D, (245) Vasopressin SNP is related to sickle cell acute care utilization for pain., J Pain , 17(4), S36, 2016 PubMed
Created on 2017-02-28 11:01:50, Last reviewed on (Show full history)

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