GeneID: 22



Names

Common Name: CSNK2A1 Type: Gene
Chromosome: 20 (NC_000020.11) Locus: NG_011970.1 (CSNK2A1)
HUGO Symbol: CSNK2A1 Full Name: Casein kinase 2, alpha 1 polypeptide
Exons: 14 Introns: 13

Description:
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. Polymorphisms in this gene associated with HbF levels in β-thalassaemia patients.

Synonyms: CK2A1 , CSNK2A3 , casein kinase 2, alpha 1 polypeptide

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Lozeman FJ, Litchfield DW, Piening C, Takio K, Walsh KA, Krebs EG, Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II., Biochemistry , 29(36), 8436-47, 1990 PubMed
  2. Yang-Feng TL, Zheng K, Kopatz I, Naiman T, Canaani D, Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit., Nucleic Acids Res. , 19(25), 7125-9, 1991 PubMed
  3. Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D, Cao A, Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia., Proc. Natl. Acad. Sci. U.S.A. , 105(5), 1620-5, 2008 PubMed
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 13:09:00 (Show full history)


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