GeneID: 196



Names

Common Name: LGALS3 Type: Gene
Chromosome: 14 (NC_000014.9) Locus: NG_017089.1 (LGALS3)
HUGO Symbol: LGALS3 Full Name: galectin 3
Exons: 6 Introns: 5

Description:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have binding affinity for beta-galactosides through evolutionary conserved sequence elements of carbohydrate-recognition domain (CRD). The encoded protein also contains an N-terminal proline-rich tandem repeat domain through which is able to form oligomers, allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. It plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation, exhibits antimicrobial activity against bacteria and fungi, and plays a key role in phagocytosis of opsonized erythrocytes. It is considered a key molecule in the host defense against pneumococcal infection by augmenting neutrophil function. Polymoprhisms in the LGALS3 gene that affect serum galectin 3 levels have been associated with frequent respiratory tract infection and vaso-occlusive crisis in children with sickle cell anaemia. Alternate splicing results in multiple transcript variants.

Synonyms: L31 , GAL3 , MAC2 , CBP35 , GALBP , GALIG , LGALS2

Comments:
N/A

Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Dumic J, Dabelic S, Flögel M, Galectin-3: an open-ended story., Biochim. Biophys. Acta , 1760(4), 616-35, 2006 PubMed
  2. Farnworth SL, Henderson NC, Mackinnon AC, Atkinson KM, Wilkinson T, Dhaliwal K, Hayashi K, Simpson AJ, Rossi AG, Haslett C, Sethi T, Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function., Am. J. Pathol. , 172(2), 395-405, 2008 PubMed
  3. Henderson NC, Sethi T, The regulation of inflammation by galectin-3., Immunol. Rev. , 230(1), 160-71, 2009 PubMed
  4. Mendonça Belmont TF, do Ó KP, Soares da Silva A, de Melo Vilar K, Silva Medeiros F, Silva Vasconcelos LR, Mendonça Dos Anjos AC, Domingues Hatzlhofer BL, Pitta MG, Bezerra MA, Araújo Ada S, de Melo Rego MJ, Moura P, Cavalcanti Mdo S, Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia., PLoS ONE , 11(9), e0162297, 2016 PubMed
Created on 2017-01-17 13:55:38, Last reviewed on (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.

Please publish modules in offcanvas position.