GeneID: 195


Common Name: MAP2K6 Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NG_029437.1 (MAP2K6)
HUGO Symbol: MAP2K6 Full Name: mitogen-activated protein kinase kinase 6
Exons: 12 Introns: 11

MAP2K6 is a member of the mitogen-activated kinase kinase (MAPKK) family that forms part of a three-tiered core-signalling module (MAP3K→MAPKK→MAPK), a common mechanism of intracellular signal transduction. MAPKK (or MEK2) is a dual specificity protein kinase, which phosphorylates and activates downstream target regulatory molecules that act as an integration point for multiple biochemical signals. Four distinct MAP kinase (MAPK) cascades have been elucidated, namely ERKs, JNK, p38 and BMK. Specifically, MAP2K6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, the MAP2K6 gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. A polymophism in this gene associated with plasma erythropoietin levels in cohorts of SCD patients.

Synonyms: MEK6 , MKK6 , MAPKK6 , PRKMK6 , SAPKK3 , SAPKK-3


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Publications / Origin

  1. Bromberg-White JL, Andersen NJ, Duesbery NS, MEK genomics in development and disease., Brief Funct Genomics , 11(4), 300-10, 2012 PubMed
  2. Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR, A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease., Hum. Mol. Genet. , 2016 PubMed
Created on 2017-01-16 13:20:41, Last reviewed on (Show full history)

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