GeneID: 192



Names

Common Name: CYP1A1 Type: Gene
Chromosome: 15 (NC_000015.10) Locus: NG_008431.2 (CYP1A1)
HUGO Symbol: CYP1A1 Full Name: cytochrome P450 family 1 subfamily A member 1
Exons: 14 Introns: 13

Description:
CYP1A1 is a member of the cytochrome P450 (CYP450) superfamily of heme-thiolate proteins that catalyze the oxidation of various endogenous and xenobiotic substrates in the metabolic pathway. It is mainly expressed in extrahepatic tissues and known for the metabolic activation of carcinogens (e.g.: polycyclic aromatic hydrocarbons (PAHs) in tobacco smoke) to epoxide intermediates, which are further activated to more reactive diol-epoxides by the enzyme epoxide hydrolase. The transcription of CYP1A1 is induced through AhR (arylhydrocarbon receptor) in the cytosol. Upon binding, AhR translocates to the nucleus where it dimerizes with ARNT (aryl hydrocarbon nuclear translocator), followed by binding to consensus regulatory sequences termed AhREs (Aryl hydrocarbon response elements), XREs (Xenobiotic response elements) or DREs (Dioxin response elements) in the promoter region of CYP1A1, thereby recruiting RNApol-II (possibly in co-operation with other proteins) to activate transcription. Polymorphisms in this gene appear to change CYP1A1 expression and function, and to influence the balance between metabolic activation and detoxification of carinogens. Some polymorphisms associated with variable individual susceptibilities to cancer. Others associated with variable plasma levels of deferasirox, and thereby variable drug response, in a cohort of β-thalassaemia patients with transfusional iron overload.

Synonyms: AHH , AHRR , CP11 , CYP1 , CYPIA1 , P1-450 , P450-C , P450DX

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Shimada T, Fujii-Kuriyama Y, Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1., Cancer Sci. , 95(1), 1-6, 2004 PubMed
  2. Androutsopoulos VP, Tsatsakis AM, Spandidos DA, Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention., BMC Cancer , 9(0), 187, 2009 PubMed
  3. Khlifi R, Messaoud O, Rebai A, Hamza-Chaffai A, Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers., Biomed Res Int , 2013(0), 582768, 2013 PubMed
  4. Cusato J, Allegra S, Massano D, De Francia S, Piga A, D'Avolio A, Influence of single-nucleotide polymorphisms on deferasirox C trough levels and effectiveness., Pharmacogenomics J. , 15(3), 263-71, 2015 PubMed
Created on 2016-10-25 17:44:59, Last reviewed on 2016-10-26 09:14:28 (Show full history)


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