GeneID: 176


Common Name: SELE Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_012124.1 (SELE)
HUGO Symbol: SELE Full Name: selectin E
Exons: 14 Introns: 13

This gene encodes E-selectin, an adhesion molecule expressed on endothelium in response to inflammatory stimulation. It is a member of the family of C-type lectins, which are involved in leukocyte adhesion and rolling on the vascular endothelium. E-selectin binds to glycoproteins containing the tetrassacharide sialyl Lewis x (sLE x) in a calcium-dependent manner. Compared to other selectins, E-selectin has a diverse set of ligands and enables slow rolling on the order of a micron per second. Rolling transduces signals that trigger β2 integrin activation, which leads to firm leukocyte arrest and transmigration to sites of injury. E-selectin co-operates with the chemokine receptor CXCR-2 to facilitate this process. It plays a role in inflammation. It has an important role during haematopoietic stem/progenitor cell trafficking to the bone marrow niche. A polymoprhism in this gene presents a risk factor of venous thrombosis in patients with HbH disease.

Synonyms: ELAM , ESEL , CD62E , ELAM1 , LECAM2


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Publications / Origin

  1. Sperandio M, Selectins and glycosyltransferases in leukocyte rolling in vivo., FEBS J. , 273(19), 4377-89, 2006 PubMed
  2. Zarbock A, Ley K, McEver RP, Hidalgo A, Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow., Blood , 118(26), 6743-51, 2011 PubMed
  3. Chase SD, Magnani JL, Simon SI, E-selectin ligands as mechanosensitive receptors on neutrophils in health and disease., Ann Biomed Eng , 40(4), 849-59, 2012 PubMed
  4. Winkler IG, Barbier V, Nowlan B, Jacobsen RN, Forristal CE, Patton JT, Magnani JL, Lévesque JP, Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance., Nat. Med. , 18(11), 1651-7, 2012 PubMed
  5. Katayama Y, Selective E-selectin ligands., Blood , 122(24), 3858-60, 2013 PubMed
  6. Sun NA, Cheng P, Deng DH, Liu RR, Lai YR, Analysis of the genetic variants associated with recurrent thromboembolism in a patient with hemoglobin H disease following splenectomy: A case report., Biomed Rep , 5(1), 23-26, 2016 PubMed
Created on 2016-10-06 08:58:43, Last reviewed on (Show full history)

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