GeneID: 175


Common Name: F2 Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NG_008953.1 (F2)
HUGO Symbol: F2 Full Name: coagulation factor II, thrombin
Exons: 14 Introns: 13

The F2 gene encodes coagulation factor II (also called prothrombin), an essential component in the blood coagulation cascade. This factor is a vitamin K-dependent glycoprotein synthesized in the liver as an inactive precursor. It is proteolytically cleaved to form the serine protease thrombin by the prothrombinase complex, which consists of factor Xa, factor Va and Ca2+ assembled on an anionic phospholipid membrane. The activated thrombin enzyme plays an important role in haemostasis and thrombosis; it converts fibrinogen to fibrin for blood clot formation, stimulates platelet aggregation, and activates coagulation factors V, VIII, and XIII. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants.

Synonyms: prepro-coagulation factor II , PT , THPH1 , RPRGL2


Sequence Viewer

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Publications / Origin

  1. Glenn KC, Frost GH, Bergmann JS, Carney DH, Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis., Pept. Res. , 1(2), 65-73, 1988 PubMed
Created on 2016-09-29 18:08:41, Last reviewed on (Show full history)

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