GeneID: 167


Common Name: AGT Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_008836.1 (AGT)
HUGO Symbol: AGT Full Name: angiotensinogen
Exons: 5 Introns: 4

The AGT gene encodes the plasma protein angiotensinogen, which serves as the precursor of angiotensin, a peptide hormone involved in the regulation of blood pressure, body fluid and electrolyte homeostasis. Angiotensinogen is mainly synthesized by the liver and is the only known substrate of renin, a protease secreted by the juxtaglomerular cells of the kidney. Its production can be enhanced by angiotensin II in a positive feedback loop, as well as plasma corticosteroid, estrogen and thyroxine hormone levels. Polymorphisms in this gene associated with risk of stroke in individuals with sickle cell disease.

Synonyms: ANHU , SERPINA8


Sequence Viewer

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Publications / Origin

  1. Weir MR, Dzau VJ, The renin-angiotensin-aldosterone system: a specific target for hypertension management., Am. J. Hypertens. , 12(12), 205S-213S, 1999 PubMed
  2. Tang DC, Prauner R, Liu W, Kim KH, Hirsch RP, Driscoll MC, Rodgers GP, Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study., Am. J. Hematol. , 68(3), 164-9, 2001 PubMed
Created on 2016-07-21 09:32:45, Last reviewed on (Show full history)

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