GeneID: 166


Common Name: CCL5 Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NG_015990.1 (CCL5)
HUGO Symbol: CCL5 Full Name: C-C motif chemokine ligand 5
Exons: 3 Introns: 2

This gene encodes for chemokine (C-C motif) ligand 5 (CCL5), also known as RANTES (Regulated upon Activation, Normally T-cell Expressed and Secreted). CCL5 plays a key role in the regulation of immune response. It functions as a chemoattractant for a variety of leukocytes, including T-cells, basophils and eosinophils, to the site of inflammation. It causes the release of histamine from basophils and activates eosinophils. It also induces the activation of natural killer cells into chemokine-activated killers (CHAK). It functions as an HIV-suppressive factor produced by CD8+ T-cells. CCL5 functions through activation of G-protein-coupled receptors (GPCRs), mainly the C-C chemokine receptor type 5 (CCR5). CCL5 has been linked to cancer progression and metastasis. Polymorphisms in this gene associated with risk of bacterial infection in individuals with sickle cell disease.

Synonyms: RANTES , SCYA5 , D17S136E , MGC17164 , SISd , TCP228


Sequence Viewer

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Publications / Origin

  1. Dossou-Yovo OP, Zaccaria I, Benkerrou M, Hauchecorne M, Alberti C, Rahimy MC, Elion J, Lapoumeroulie C, Effects of RANTES and MBL2 gene polymorphisms in sickle cell disease clinical outcomes: association of the g.In1.1T>C RANTES variant with protection against infections., Am. J. Hematol. , 84(6), 378-80, 2009 PubMed
  2. Aldinucci D, Colombatti A, The inflammatory chemokine CCL5 and cancer progression., Mediators Inflamm. , 2014(0), 292376, 2014 PubMed
Created on 2016-07-21 09:28:22, Last reviewed on 2016-08-09 11:05:35 (Show full history)

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