GeneID: 156


Common Name: IL6 Type: Gene
Chromosome: 7 (NC_000007.14) Locus: NG_011640.1 (IL6)
HUGO Symbol: IL6 Full Name: interleukin 6
Exons: 6 Introns: 5

The encoded protein is a pleiotropic cytokine. It is involved in the process of innate immunity, stimulating end-stage B-cell differentiation, immunoglobulin secretion, T-cell activation, as well as hepatocytes to induce synthesis of acute-phase proteins. Binding of the IL-6 to its receptor (IL-6R) forms a complex with ability to bind a second receptor protein, glycoprotein (gp) 130, that in turn activates downstream signal transducers. IL-6 plays a critical role in the generation and propagation of chronic inflammation; IL-6 signalling is implicated in altering the composition of the leukocyte infiltrate at the site of injury and thus facilitating the transition from acute to chronic inflammation. Increased levels of circulating IL-6 are linked to several inflammatory diseases, including diabetes mellitus and systemic juvenile rheumatoid arthritis. Polymorphisms in this gene associated with higher likelihood of retinopathy and leg ulcers in sickle cell disease patients. Alternative splicing of this gene results in mutliple transcript variants.

Synonyms: BSF2 , HGF , HSF , IL-6 , interferon beta 2


Sequence Viewer

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Publications / Origin

  1. Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S, The pro- and anti-inflammatory properties of the cytokine interleukin-6., Biochim. Biophys. Acta , 1813(5), 878-88, 2011 PubMed
  2. Schmidt-Arras D, Rose-John S, IL-6 pathway in the liver: From physiopathology to therapy., J. Hepatol. , 64(6), 1403-15, 2016 PubMed
Created on 2016-05-26 11:47:32, Last reviewed on 2017-07-19 10:38:41 (Show full history)

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