GeneID: 155


Common Name: IL1B Type: Gene
Chromosome: 2 (NC_000002.12) Locus: NG_008851.1 (IL1B)
HUGO Symbol: IL1B Full Name: interleukin 1 beta
Exons: 7 Introns: 6

The encoded protein is a potent proinflammatory cytokine, member of the interleukin 1 cytokine family. It plays an essential role in the regulation of immune responses and has been linked to the pathogenesis of diverse autoimmune and inflammatory diseases, such as rheumatoid arthritis. IL-1β is produced by a variety of cell types, such as haematopoietic cells and tissue macrophages, as an inactive 31 kDa precursor. The IL-1β precursor is proteolytically cleaved to its active form by the proinflammatory protease caspase-1, which is itself activated via recruitment to a multi-protein complex termed the inflammasome. This cytokine binds to specific receptors of the IL-1R family to exert diverse biological processes. Polymorphisms in this gene have been implicated in vaso-occlusion through the processes of inflammation, cellular adhesion, signalling, transport or coagulation in sickle cell disease patients.

Synonyms: IL-1B , IL1-BETA , IL1F2


Sequence Viewer

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Publications / Origin

  1. Santamaria P, Cytokines and chemokines in autoimmune disease: an overview., Adv. Exp. Med. Biol. , 520(0), 1-7, 2003 PubMed
  2. Lopez-Castejon G, Brough D, Understanding the mechanism of IL-1β secretion., Cytokine Growth Factor Rev. , 22(4), 189-95, 2011 PubMed
  3. Garlanda C, Dinarello CA, Mantovani A, The interleukin-1 family: back to the future., Immunity , 39(6), 1003-18, 2013 PubMed
  4. Vicari P, Adegoke SA, Mazzotti DR, Cançado RD, Nogutti MA, Figueiredo MS, Interleukin-1β and interleukin-6 gene polymorphisms are associated with manifestations of sickle cell anemia., Blood Cells Mol. Dis. , 54(3), 244-9, 2015 PubMed
Created on 2016-05-26 11:41:47, Last reviewed on (Show full history)

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