GeneID: 142


Common Name: CCL2 Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NG_012123.1 (CCL2)
HUGO Symbol: CCL2 Full Name: C-C motif chemokine ligand 2
Exons: 3 Introns: 2

The encoded protein belongs to the large family of chemokines, which play a central role in immunoregulatory and inflammatory processess. Chemokines are classified based on the arrangement of N-terminal cysteine residues into four major families. CCL2 is a member of the C-C motif family, which is characterized by two adjacent cysteine residues. It mainly functions to recruit and activate monocytes and T cells to sites of injury and infection. It is involved in the establishment and maintenance of granuloma in latent infection. It is implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. It is also implicated in prostate cancer tumorigenesis and metastasis. Polymorphisms in this gene associated with stroke in sickle cell patients.

Synonyms: GDCF-2 , HC11 , MCAF , MCP-1 , MCP1 , MGC9434 , SCYA2 , SMC-CF


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Publications / Origin

  1. Mehrabian M, Sparkes RS, Mohandas T, Fogelman AM, Lusis AJ, Localization of monocyte chemotactic protein-1 gene (SCYA2) to human chromosome 17q11.2-q21.1., Genomics , 9(1), 200-3, 1991 PubMed
  2. Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005 PubMed
  3. Zhang J, Lu Y, Pienta KJ, Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth., J. Natl. Cancer Inst. , 102(8), 522-8, 2010 PubMed
  4. Hussain R, Ansari A, Talat N, Hasan Z, Dawood G, CCL2/MCP-I genotype-phenotype relationship in latent tuberculosis infection., PLoS ONE , 6(10), e25803, 2011 PubMed
Created on 2016-05-04 16:57:38, Last reviewed on (Show full history)

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