GeneID: 120


Common Name: TNF Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NG_007462.1 (TNF)
HUGO Symbol: TNF Full Name: tumor necrosis factor
Exons: 4 Introns: 3

The encoded protein is a potent pro-inflammatory cytokine, part of the tumor necrosis factor (TNF) superfamily, derived predominantly from activated macrophages. It acts on various signalling pathways through specific cell surface receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR to regulate NF-kB activation of inflammation, stress-activated protein kinases, and apoptotic pathways. It functions mainly in the containment of local infection and is involved in the regulation of several biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism and coagulation. It has also been implicated in noninfectious inflammatory diseases, including rheumatoid arthritis, osteoarthritis, atheroschlerosis, insulin resistance, Alzheimer's disease and cancer. Polymorphisms in this gene associated with stroke in sickle cell patients.

Synonyms: DIF , TNFA , TNFSF2 , TNLG1F , TNF-alpha


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Publications / Origin

  1. Hoppe C, Klitz W, Cheng S, Apple R, Steiner L, Robles L, Girard T, Vichinsky E, Styles L, , Gene interactions and stroke risk in children with sickle cell anemia., Blood , 103(6), 2391-6, 2004 PubMed
  2. Hoppe C, Klitz W, D'Harlingue K, Cheng S, Grow M, Steiner L, Noble J, Adams R, Styles L, , Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia., Stroke , 38(8), 2241-6, 2007 PubMed
  3. Zhang JM, An J, Cytokines, inflammation, and pain., Int Anesthesiol Clin , 45(2), 27-37, 2007 PubMed
  4. Flanagan JM, Frohlich DM, Howard TA, Schultz WH, Driscoll C, Nagasubramanian R, Mortier NA, Kimble AC, Aygun B, Adams RJ, Helms RW, Ware RE, Genetic predictors for stroke in children with sickle cell anemia., Blood , 117(24), 6681-4, 2011 PubMed
  5. Schulte W, Bernhagen J, Bucala R, Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view., Mediators Inflamm. , 2013(0), 165974, 2013 PubMed
Created on 2016-04-27 15:12:26, Last reviewed on (Show full history)

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