GeneID: 104



Names

Common Name: UGT2B7 Type: Gene
Chromosome: 4 (NC_000004.12) Locus: N/A
HUGO Symbol: UGT2B7 Full Name: UDP glucuronosyltransferase family 2 member B7
Exons: 6 Introns: 5

Description:
UGT2B7 is a member of the enzyme family of UGTs [UDT (uridine diphosphate) glucuronosyltransferases] that catalyse the addition of glucuronic acid to a diverse array of lipophilic compounds in order to mediate their biotransformation into soluble derivatives for excretion in urine and bile. The UGT2B7 gene is part of a complex locus encoding several UGTs that are classified by sequence homology into two major families, UGT1A and UGT2. The UGT2 family consists of nine members. The encoded protein is localised in the microsome membrane and participates in the detoxification of endobiotic molecules, such as bile acid and steroid hormones, therapeutic drugs and environmental toxins. It has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. It also functions as an important hepatic enzyme for the glucuronidation of morphine-based opioids. Polymorphisms in this gene associated with vaso-occlusive crises in sickle cell patients.

Synonyms: UGT2B9 , UDPGTH2 , UDPGT2B7 , UDPGT 2B9

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Czernik PJ, Little JM, Barone GW, Raufman JP, Radominska-Pandya A, Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa., Drug Metab. Dispos. , 28(10), 1210-6, 2000 PubMed
  2. Miley MJ, Zielinska AK, Keenan JE, Bratton SM, Radominska-Pandya A, Redinbo MR, Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7., J. Mol. Biol. , 369(2), 498-511, 2007 PubMed
  3. Darbari DS, van Schaik RH, Capparelli EV, Rana S, McCarter R, van den Anker J, UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease., Am. J. Hematol. , 83(3), 200-2, 2008 PubMed
  4. Fertrin KY, Costa FF, Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment., Expert Rev Hematol , 3(4), 443-58, 2010 PubMed
Created on 2016-04-27 11:36:44, Last reviewed on 2016-04-27 11:38:22 (Show full history)


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