GeneID: 370



Names

Common Name: Mi-2a Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NM_001005273.3 (CHD3)
HUGO Symbol: CHD3 Full Name: chromodomain helicase DNA binding protein 3
Exons: 40 Introns: 39

Description:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD3 is a key component of NuRD, a protein complex that comprises both nucleosome remodeling and deacetylase activities. The NuRD complex has been associated with epigenetic mechanisms of transcriptional repression during development, and has been shown to play an important role in globin regulation.

Synonyms: ZFH , SNIBCPS , Mi2-ALPHA

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Bauer DE, Kamran SC, Orkin SH, Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders., Blood, 120(15), 2945-53, 2012 PubMed
  2. Thein SL, Genetic association studies in β-hemoglobinopathies., Hematology Am Soc Hematol Educ Program, 2013(0), 354-61, 2013 PubMed
  3. Hoffmeister H, Fuchs A, Erdel F, Pinz S, Gröbner-Ferreira R, Bruckmann A, Deutzmann R, Schwartz U, Maldonado R, Huber C, Dendorfer AS, Rippe K, Längst G, CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality., Nucleic Acids Res., 45(18), 10534-10554, 2017 PubMed
Created on 2020-03-27 17:38:19, Last reviewed on (Show full history)


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