GeneID: 278

Description:
The MYBBP1A gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the MYB proto-oncogene protein. MYB is predominantly expressed in immature haemopoietic cells where it plays an important role in haemopoietic cell proliferation and differentiation, and has been recognized as an important QTL in the modulation of Hb F gene expression. MYBBP1A is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. A variation in MYBBP1A associated with Hb F response to hydroxyurea in sickle cell disease cohorts.

Synonyms: P160 , PAP2 , FLJ37886 , Pol5

Comments:
N/A

Number of entries/variants: 1

1. Mori S, Bernardi R, Laurent A, Resnati M, Crippa A, Gabrieli A, Keough R, Gonda TJ, Blasi F, Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor., PLoS ONE, 7(10), e39723, 2012 PubMed
2. Hochstatter J, Hölzel M, Rohrmoser M, Schermelleh L, Leonhardt H, Keough R, Gonda TJ, Imhof A, Eick D, Längst G, Németh A, Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA., J. Biol. Chem., 287(29), 24365-77, 2012 PubMed
3. Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM, Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., PLoS ONE , 9(10), e110740, 2014 PubMed
4. Wang X, Angelis N, Thein SL, MYB - A regulatory factor in hematopoiesis., Gene, 665(0), 6-17, 2018 PubMed