GeneID: 254



Names

Common Name: OR10G9 Type: Gene
Chromosome: 11 (NC_000011.10) Locus: N/A
HUGO Symbol: OR10G9 Full Name: olfactory receptor family 10 subfamily G member 9
Exons: 1 Introns: N/A

Description:
Olfactory receptors (ORs) are members of a large family of G-protein-coupled receptors (GPCR) that transverse the membrane seven times and are located on the sensory neurons of nasal epithelium. The OR gene family is the largest in the genome and exists as clusters of genes in specific genomic locations. ORs bind to odorant molecules and transduce signals via a G protein, in turn activating downstream effector molecules that trigger the perception of smell. The olfactory system is highly discriminating and each OR can be activated by multiple odorants of similar structure. The ORs are grouped into subfamilies based on the type of odorant structure detected. OR10G9 encodes the olfactory receptor family 10 subfamily G member 9. The nomenclature assigned to the OR genes and proteins for this organism is independent of other organisms. The β-globin gene locus is surrounded by a large cluster of OR genes. A OR10G9 variant associated with the total number of white blood cells and neutrophils in sickle cell disease.

Synonyms: OR10G10P

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R, Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters., Proc. Natl. Acad. Sci. U.S.A. , 97(26), 14560-5, 2000 PubMed
  2. Malnic B, Godfrey PA, Buck LB, The human olfactory receptor gene family., Proc. Natl. Acad. Sci. U.S.A. , 101(8), 2584-9, 2004 PubMed
  3. Schaefer BA, Flanagan JM, Alvarez OA, Nelson SC, Aygun B, Nottage KA, George A, Roberts CW, Piccone CM, Howard TA, Davis BR, Ware RE, Genetic Modifiers of White Blood Cell Count, Albuminuria and Glomerular Filtration Rate in Children with Sickle Cell Anemia., PLoS ONE , 11(10), e0164364, 2016 PubMed
Created on 2019-03-19 11:43:44, Last reviewed on (Show full history)


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