IthaID: 3303
Names and Sequences
| Functionality: | Disease modifying mutation | Pathogenicity: | N/A |
|---|---|---|---|
| Common Name: | rs4274224 | HGVS Name: | NG_008841.1:g.31550C>T |
Context nucleotide sequence:
AGGGGACTGGGGTCAGGCCTCATTC [A/G] GGTTCCCTAGAGTGGAAAGGATTGG (Strand: +)
Also known as:
Comments: SNP associated with vaso-occlusive crisis episodes in sickle cell disease in Cameroon.
We follow the HGVS sequence variant nomenclature and IUPAC standards.
External Links
Phenotype
| Allele Phenotype (Cis): | N/A |
|---|---|
| Allele Phenotype (Trans): | N/A |
| Associated Phenotypes: | Vaso-occlusive crisis |
Location
| Chromosome: | 11 |
|---|---|
| Locus: | NG_008841.1 |
| Locus Location: | 31550 |
| Size: | 1 bp |
| Located at: | DRD2 |
| Specific Location: | Intron 1 |
Other details
| Type of Mutation: | Point-Mutation(Substitution) |
|---|---|
| Effect on Gene/Protein Function: | N/A |
| Ethnic Origin: | Cameroonian |
| Molecular mechanism: | N/A |
| Inheritance: | Quantitative trait |
| DNA Sequence Determined: | Yes |
In silico pathogenicity prediction
Publications / Origin
- Wonkam A, Mnika K, Ngo Bitoungui VJ, Chetcha Chemegni B, Chimusa ER, Dandara C, Kengne AP, Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon., Br. J. Haematol. , 180(1), 134-146, 2018
Created on 2018-01-31 17:59:07,
Last reviewed on 2018-01-31 18:00:44 (Show full history)
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