GeneID: 95


Common Name: PDS5B Type: Gene
Chromosome: 13 (NC_000013.11) Locus: NG_021308.1 (PDS5B)
HUGO Symbol: PDS5B Full Name: PDS5 cohesin associated factor B
Exons: 35 Introns: 34

PDS5 is a cohesin-associated protein that exists in two isoforms in vertebrates, PDS5A and PDS5B. Cohesin is a multi-protein complex that associates with chromosomes and mediates cohesion of sister chromatids during S phase. The PDS5-like proteins appear to modulate the stability of the cohesin complex association with chromatin and facilitate accurate chromosomal segregation during cell division. This protein also plays a role in androgen-induced proliferative arrest in prostate cells and may be a tumor-suppressor gene. Polymorphisms in this gene associated with leg ulceration and osteonecrosis in sickle cell patients.

Synonyms: AS3 , APRIN , CG008


Publications / Origin

  1. Geck P, Maffini MV, Szelei J, Sonnenschein C, Soto AM, Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator., Proc. Natl. Acad. Sci. U.S.A. , 97(18), 10185-90, 2000
  2. Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, Bisbee A, Farrell J, Farrer L, Steinberg MH, Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis., Blood , 106(1), 372-5, 2005
  3. Losada A, Yokochi T, Hirano T, Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts., J. Cell. Sci. , 118(0), 2133-41, 2005
  4. Nolan VG, Adewoye A, Baldwin C, Wang L, Ma Q, Wyszynski DF, Farrell JJ, Sebastiani P, Farrer LA, Steinberg MH, Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway., Br. J. Haematol. , 133(5), 570-8, 2006
  5. Peters JM, Nishiyama T, Sister chromatid cohesion., Cold Spring Harb Perspect Biol , 4(11), , 2012
Created on 2016-04-27 09:32:11, Last reviewed on (Show full history)

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