GeneID: 8

Names

Common Name:	Gγ	Type:	Gene
Chromosome:	11 (NC_000011.10)	Locus:	NG_000007.3 (β-locus)
HUGO Symbol:	HBG2	Full Name:	hemoglobin subunit gamma 2
Exons:	3	Introns:	2

Description:
The γ-globin genes (HBG1 and HBG2) are active during fetal growth and are normally expressed in the fetal liver, spleen and bone marrow. The combination of two γ-globin chains and two α-globin chains forms fetal haemoglobin (HbF; α2γ2). HbF is normally replaced by adult haemoglobin (HbA) at birth. The HBG genes are the result of a 5 kb tandem duplication and differ at position 136 of the HBG chain to encode glutamic acid (Gγ; HBG2) or alanine (Aγ; HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-ε(HBE)-Gγ(HBG2)-Aγ(HBG1)-ψβ(HBBP1)-δ(HBD)-β(HBB)-3'.

Synonyms: HBG-T1

Comments:
N/A

Number of entries/variants: 143

External Links

NCBI Gene	UniProtKB
PDB	HGNC
OMIM

IthaScore

Publications / Origin

Slightom JL, Blechl AE, Smithies O, Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes., Cell , 21(3), 627-38, 1980

Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 10:44:31 (Show full history)

A/A	Date	Curator(s)	Comments
1	2014-04-01 14:19:10	The IthaGenes Curation Team	Created
2	2014-04-09 18:29:45	The IthaGenes Curation Team	Reviewed.
3	2016-04-28 10:44:31	The IthaGenes Curation Team	Reviewed.

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