GeneID: 75


Common Name: NOX3 Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NG_011995.1 (NOX3)
HUGO Symbol: NOX3 Full Name: NADPH oxidase 3
Exons: 14 Introns: 13

NOX3 is a member of the NOX family of NADPH oxidases, involved in the generation of reactive oxygen species (ROS) for signalling and host defense. NADPH oxidases form part of a multicomponent enzyme system, which assembles at membrane sites upon cell activation and mediates transfer of electrons from NADPH inside the cell across the plasma membrane to molecular oxygen (O2), in order to produce superoxide (O2-). Superoxide is the precursor of most other ROS, such as hydrogen peroxide and hydroxyl radical. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Polymorphisms in this gene associated with HbF levels in sickle cell patients.

Synonyms: MOX-2 , GP91-3


Sequence Viewer

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Publications / Origin

  1. Groemping Y, Rittinger K, Activation and assembly of the NADPH oxidase: a structural perspective., Biochem. J. , 386(0), 401-16, 2005 PubMed
  2. Sebastiani P, Wang L, Nolan VG, Melista E, Ma Q, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations., Am. J. Hematol. , 83(3), 189-95, 2008 PubMed
  3. Panday A, Sahoo MK, Osorio D, Batra S, NADPH oxidases: an overview from structure to innate immunity-associated pathologies., Cell. Mol. Immunol. , 12(1), 5-23, 2015 PubMed
Created on 2016-04-26 15:17:06, Last reviewed on 2016-04-26 15:19:12 (Show full history)

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