GeneID: 69
Names
| Common Name: | SPARC | Type: | Gene |
|---|---|---|---|
| Chromosome: | 5 (NC_000005.10) | Locus: | NG_042174.1 (SPARC) |
| HUGO Symbol: | SPARC | Full Name: | secreted protein acidic and cysteine rich |
| Exons: | 10 | Introns: | 9 |
Description:
The encoded protein is a cysteine-rich acidic matricellular glycoprotein. It functions as a critical modulator of cellular interaction with the extracellular matrix (ECM) and is restricted mainly in remodelling tissues, such as bone, gut mucosa and wound healing. It binds to several ECM components and exhibits counter-adhesive effects that lead to changes in cell shape and in cell-matrix contact. It is associated with biological processes, such as morphogenesis, mineralization and angiogenesis, as well as with pathological response to injury, inflammation and tumorigenesis. It inhibits the cell cycle and thus cellular proliferation and migration. It is prominent in tumors and in disorders associated with fibrosis, and is linked to human obesity, insulin resistance, and diabetic retinopathy. Polymorphisms in this gene associated with HbF levels in sickle cell patients. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms: ON , OI17 , BM-40
Comments:
N/A
Number of entries/variants: 3
Publications / Origin
- Yan Q, Sage EH, SPARC, a matricellular glycoprotein with important biological functions., J. Histochem. Cytochem. , 47(12), 1495-506, 1999
- Brekken RA, Sage EH, SPARC, a matricellular protein: at the crossroads of cell-matrix communication., Matrix Biol. , 19(8), 816-27, 2001
- Kos K, Wilding JP, SPARC: a key player in the pathologies associated with obesity and diabetes., Nat Rev Endocrinol , 6(4), 225-35, 2010
- Liu L, Pertsemlidis A, Ding LH, Story MD, Steinberg MH, Sebastiani P, Hoppe C, Ballas SK, Pace BS, A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease., Exp. Biol. Med. (Maywood) , 2016