GeneID: 62


Common Name: ADCY9 Type: Gene
Chromosome: 16 (NC_000016.10) Locus: NG_011434.1 (ADCY9)
HUGO Symbol: ADCY9 Full Name: adenylate cyclase 9
Exons: 11 Introns: 10

ADCY9 encodes a membrane-bound member of the guanylyl cyclase family of enzymes. The encoded protein belongs to class IV adenylyl cyclases that catalyse the conversion of ATP to cyclic AMP (cAMP) in response to signals from plasma membrane-bound G protein-coupled receptors (GPCR). ADCY9 is part of the signalling pathway of the β2-adrenergic GPCR. cAMP signals to downstream effectors, such as protein kinase A, which activate other kinase cascades that in turn modulate the activity of multiple downstream proteins. Polymorphisms in this gene associated with stroke in sickle cell patients.

Synonyms: AC9 , ACIX


Sequence Viewer

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Publications / Origin

  1. Hurley JH, Structure, mechanism, and regulation of mammalian adenylyl cyclase., J. Biol. Chem. , 274(12), 7599-602, 1999 PubMed
  2. Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA, Guanylyl cyclases and signaling by cyclic GMP., Pharmacol. Rev. , 52(3), 375-414, 2000 PubMed
  3. Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005 PubMed
  4. Flanagan JM, Frohlich DM, Howard TA, Schultz WH, Driscoll C, Nagasubramanian R, Mortier NA, Kimble AC, Aygun B, Adams RJ, Helms RW, Ware RE, Genetic predictors for stroke in children with sickle cell anemia., Blood , 117(24), 6681-4, 2011 PubMed
Created on 2016-04-26 10:45:05, Last reviewed on 2016-04-26 11:00:46 (Show full history)

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