GeneID: 6


Names

Common Name: ε Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NG_000007.3 (β-locus)
HUGO Symbol: HBE1 Full Name: hemoglobin subunit epsilon 1
Exons: 3 Introns: 2

Description:
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic haemoglobin Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic haemoglobins are normally supplanted by fetal, and later, adult haemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-ε(HBE)-Gγ(HBG2)-Aγ(HBG1)-ψβ(HBBP1)-δ(HBD)-β(HBB)-3'.

Synonyms: HBE , Epsilon-globin

Comments:
N/A

Number of entries/variants: 43

IthaScore

Publications / Origin

  1. Gale RE, Clegg JB, Huehns ER, Human embryonic haemoglobins Gower 1 and Gower 2., Nature , 280(5718), 162-4, 1979
  2. Baralle FE, Shoulders CC, Proudfoot NJ, The primary structure of the human epsilon-globin gene., Cell , 21(3), 621-6, 1980
  3. Fritsch EF, Lawn RM, Maniatis T, Molecular cloning and characterization of the human beta-like globin gene cluster., Cell , 19(4), 959-72, 1980
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 11:35:00 (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.