GeneID: 59


Common Name: ANXA2 Type: Gene
Chromosome: 15 (NC_000015.10) Locus: N/A
HUGO Symbol: ANXA2 Full Name: annexin A2
Exons: 13 Introns: 12

ANXA2 is a member of the annexin family of calcium-regulated phospholipid-binding proteins. Annexins consist of a conserved α-helical core domain that harbours the calcium-binding motif, and a second divergent domain that undergoes post-translational modifications to specify individual annexin properties. They are involved in a variety of membrane-related functions including exocytosis, endocytosis and membrane trafficking. They play important roles in the regulation of cell growth and in signal transduction pathways. ANXA2 is implicated in bone mineralization and in the generation of the thrombolytic agent plasmin. Polymorphisms in this gene associated with osteonecrosis and stroke in sickle cell patients. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms: LIP2 , ANX2


Sequence Viewer

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Publications / Origin

  1. Gillette JM, Nielsen-Preiss SM, The role of annexin 2 in osteoblastic mineralization., J. Cell. Sci. , 117(0), 441-9, 2004 PubMed
  2. Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, Bisbee A, Farrell J, Farrer L, Steinberg MH, Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis., Blood , 106(1), 372-5, 2005 PubMed
  3. Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005 PubMed
  4. Flanagan JM, Frohlich DM, Howard TA, Schultz WH, Driscoll C, Nagasubramanian R, Mortier NA, Kimble AC, Aygun B, Adams RJ, Helms RW, Ware RE, Genetic predictors for stroke in children with sickle cell anemia., Blood , 117(24), 6681-4, 2011 PubMed
  5. Bharadwaj A, Bydoun M, Holloway R, Waisman D, Annexin A2 heterotetramer: structure and function., Int J Mol Sci , 14(3), 6259-305, 2013 PubMed
Created on 2016-04-26 09:55:41, Last reviewed on 2016-05-09 14:26:15 (Show full history)

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