GeneID: 54


Common Name: BMPR1B Type: Gene
Chromosome: 4 (NC_000004.12) Locus: NG_009245.1 (BMPR1B)
HUGO Symbol: BMPR1B Full Name: bone morphogenetic protein receptor type 1B
Exons: 13 Introns: 12

BMPR1B is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The BMPs are signalling molecules that belong to the transforming growth factor β (TGFβ) family of proteins and participate in several processes including cell growth, development, morphogenesis, apoptosis and immune responses. BMPs transduce signals by binding to heteromeric complexes of type-I and type-II receptors, which in turn activate transcriptional regulators called SMADs. BMPR1B is a type I receptor. Type-II receptors bind ligands but they require their respective type-I receptors for signalling. Polymorphisms in this gene have been associated with glomerular filtration rate in sickle cell nephropathy in African Americans.

Synonyms: ALK6 , CDw293


Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Nolan VG, Ma Q, Cohen HT, Adewoye A, Rybicki AC, Baldwin C, Mahabir RN, Homan EP, Wyszynski DF, Fabry ME, Nagel RL, Farrer LA, Steinberg MH, Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B., Am. J. Hematol. , 82(3), 179-84, 2007 PubMed
  2. Miyazono K, Kamiya Y, Morikawa M, Bone morphogenetic protein receptors and signal transduction., J. Biochem. , 147(1), 35-51, 2010 PubMed
Created on 2016-04-25 17:47:01, Last reviewed on 2016-04-25 17:59:14 (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.