GeneID: 5


Common Name: βLCR Type: Regulatory Sequence
Chromosome: 11 (NC_000011.10) Locus: NG_000007.3 (β-locus)
HUGO Symbol: LCRB Full Name: locus control region, beta
Exons: N/A Introns: N/A

The haemoglobin beta (β) locus control region (LCRB) is thought to organize the entire 60-kb β-globin gene cluster into an active chromatin domain and to regulate the transcription of individual globin genes throughout development. The globin genes are arranged as 5'-ε(HBE)-Gγ(HBG2)-Aγ(HBG1)-ψβ(HBBP1)-δ(HBD)-β(HBB)-3' on the β-globin locus. The arrangement of the genes reflects the temporal differentiation of their expression during development, with the early-embryonic stage version of the gene located closest to the LCRB. If the genes are rearranged on the locus, the globin gene products are expressed at improper stages of development.

Synonyms: LCRB


External Links

Sequence Viewer

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Publications / Origin

  1. Levings PP, Bungert J, The human beta-globin locus control region., Eur. J. Biochem. , 269(6), 1589-99, 2002 PubMed
  2. Sawado T, Halow J, Bender MA, Groudine M, The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation., Genes Dev. , 17(8), 1009-18, 2003 PubMed
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 11:36:12 (Show full history)

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