GeneID: 478
Names
| Common Name: | TEAD4 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 12 (NC_000012.12) | Locus: | NG_029958.1 (TEAD4) |
| HUGO Symbol: | TEAD4 | Full Name: | TEA domain transcription factor 4 |
| Exons: | 13 | Introns: | 12 |
Description:
The TEAD4 gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. The expression of TEAD4 negative correlates with haemoglobin F (HbF) expression in beta-thalassaemia patients. Functional studies identified a TEAD4 binding motif on the γ-globin gene promoters. The disruption of this motif associated with de-repression of HbF in both β-thalassaemia CD34+ cells and HUDEP-2 cells. TEAD4 functions as a potential regulator of HbF and a candidate therapeutic option for patients with beta-haemoglobinopathies.
Synonyms: TEF3 , RTEF1 , TEF-3 , EFTR-2 , TEFR-1 , TCF13L1 , hRTEF-1B
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Lin J, Ye Y, Shang X, Zhang Y, Wei X, Xu X, TEA domain transcription factor 4 modulates repression of fetal haemoglobin by direct binding to the γ-globin gene promoters., Br J Haematol, 195(5), 764-769, 2021