GeneID: 473

Names

Common Name:	MIR451A	Type:	Gene
Chromosome:	17 (NC_000017.11)	Locus:	NR_029970.1 (MIR451A)
HUGO Symbol:	MIR451A	Full Name:	microRNA 451a
Exons:	N/A	Introns:	N/A

Description:
MicroRNAs (miRNAs), such as MIR451A, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. MIR451A enhances erythroid differentiation and is involved in oxidative stress. MIR451A is implicated in sickle cell disease (SCD) and malaria pathogenesis, and appears to be differentially expressed in plasma exosomes isolated from individuals with different sickle hemoglobin variants. Functional studies in vitro revealed an increased expression of MIR451A in HbSS and HbAS erythrocytes without malaria. Predictions of MIR451A gene targets indicate that MIR451A may alter SCD and malaria pathogenesis through inflammatory pathways. MIR451A is a candidate biomarker of pathogenesis for both diseases.

Synonyms: MIRN451 , MIR451

Comments:
N/A

Number of entries/variants: 0

External Links

NCBI Gene	HGNC
OMIM

IthaScore

Sequence Viewer

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Publications / Origin

Oxendine Harp K, Bashi A, Botchway F, Dei-Adomakoh Y, Iqbal SA, Wilson MD, Adjei AA, Stiles JK, Driss A, MicroRNAs miR-451a and Let-7i-5p Profiles in Circulating Exosomes Vary among Individuals with Different Sickle Hemoglobin Genotypes and Malaria., J Clin Med, 11(3), , 2022 PubMed

Created on 2022-03-11 12:25:55, Last reviewed on (Show full history)

A/A	Date	Curator(s)	Comments
1	2022-03-11 12:25:55	The IthaGenes Curation Team	Created

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