GeneID: 473



Names

Common Name: MIR451A Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NR_029970.1 (MIR451A)
HUGO Symbol: MIR451A Full Name: microRNA 451a
Exons: N/A Introns: N/A

Description:
MicroRNAs (miRNAs), such as MIR451A, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. MIR451A enhances erythroid differentiation and is involved in oxidative stress. MIR451A is implicated in sickle cell disease (SCD) and malaria pathogenesis, and appears to be differentially expressed in plasma exosomes isolated from individuals with different sickle hemoglobin variants. Functional studies in vitro revealed an increased expression of MIR451A in HbSS and HbAS erythrocytes without malaria. Predictions of MIR451A gene targets indicate that MIR451A may alter SCD and malaria pathogenesis through inflammatory pathways. MIR451A is a candidate biomarker of pathogenesis for both diseases.

Synonyms: MIRN451 , MIR451

Comments:
N/A

External Links

Sequence Viewer

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Publications / Origin

  1. Oxendine Harp K, Bashi A, Botchway F, Dei-Adomakoh Y, Iqbal SA, Wilson MD, Adjei AA, Stiles JK, Driss A, MicroRNAs miR-451a and Let-7i-5p Profiles in Circulating Exosomes Vary among Individuals with Different Sickle Hemoglobin Genotypes and Malaria., J Clin Med, 11(3), , 2022 PubMed
Created on 2022-03-11 12:25:55, Last reviewed on (Show full history)


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