GeneID: 467


Names

Common Name: NFE2 Type: Gene
Chromosome: 12 (NC_000012.12) Locus: NM_001136023.3 (NFE2 )
HUGO Symbol: NFE2 Full Name: Nuclear Factor, Erythroid 2
Exons: 3 Introns: 2

Description:
NF-E2 is a transcription factor that binds to the β-globin locus control region (LCR) hypersensitive site 2 (HS2) and with the β-globin gene promoter. It is a is a heterodimer composed of the haematopoietic specific subunit p45 and a ubiquitously expressed subunit p18 (small Maf protein). It plays a critical role in the regulation of erythroid and megakaryocytic maturation and differentiation. May play a role in all aspects of haemoglobin production from globin and heme synthesis to procurement of iron.

Synonyms: NF-E2

Comments:
N/A

Publications / Origin

  1. Woon Kim Y, Kim S, Geun Kim C, Kim A, The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes., Nucleic Acids Res, 39(16), 6944-55, 2011
Created on 2022-01-04 17:31:56, Last reviewed on (Show full history)


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