GeneID: 465


Common Name: RANKL Type: Gene
Chromosome: 13 (NC_000013.11) Locus: NG_008990.1 (TNFSF11)
HUGO Symbol: TNFSF11 Full Name: TNF superfamily member 11
Exons: 5 Introns: 4

The TNFSF11 gene, also known as RANKL (Receptor Activator of NF-κB ligand), encodes a member of the tumor necrosis factor (TNF) cytokine family and functions as a key factor for osteoclast differentiation and activation by interacting with its specific receptor RANK, expressed in osteoclast precursors and mature osteoclasts, thereby increasing levels of bone resorption. Osteoprotegerin (OPG) [GeneID: 466], a soluble decoy receptor for RANKL, inhibits the RANKL/RANK interaction and arrests osteoclastogenesis and bone loss. TNFSF11 (RANKL) is expressed by T cells during bone metabolism and also functions in the immune system through dendritic cell activation. Studies reported that the RANK/RANKL/OPG system may have an important role in regulating bone metabolism in transfusion-dependent β-thalassemia patients.

Synonyms: RANKL , ODF , OPGL , sOdf , CD254 , OPTB2 , TNLG6B , TRANCE , hRANKL2


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Publications / Origin

  1. Ono T, Hayashi M, Sasaki F, Nakashima T, RANKL biology: bone metabolism, the immune system, and beyond., Inflamm Regen, 40(0), 2, 2020 PubMed
  2. Youssry I, Saad N, Madboly M, Samy RM, Hamed ST, Tawfik H, Elbatrawy SR, Kaddah N, Abd Elaziz D, Bone health in pediatric transfusion-dependent beta-thalassemia: Circulating osteoprotegerin and RANKL system., Pediatr Blood Cancer, 69(1), e29377, 2022 PubMed
Created on 2021-12-29 10:16:47, Last reviewed on 2021-12-29 10:21:47 (Show full history)

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