GeneID: 462


Common Name: PLSCR4 Type: Gene
Chromosome: 3 (NC_000003.12) Locus: NM_020353.3 (PLSCR4)
HUGO Symbol: PLSCR4 Full Name: phospholipid scramblase 4
Exons: 9 Introns: 8

The PLSCR4 gene encodes phospholipid scramblase 4, a member of phospholipid scramblases, which constitute a group of single pass, plasma membrane proteins mediating Ca2+ induced ATP independent bidirectional trans‑bilayer movement of phospholipids between the two leaflets of plasma membrane. Phospholipid scramblases play vital roles in key cellular processes, including tumorigenesis, antiviral defense, protein and DNA interactions, transcriptional regulation and apoptosis. PLSCR4 is expressed in a variety of tissues and may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. The PLSCR4 gene was significantly upregulated in patients with sickle cell disease (SCD) during vaso-occlusive crisis (VOC), and poses a candidate genetic marker for the development of VOC in SCD.

Synonyms: TRA1


Sequence Viewer

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Publications / Origin

  1. Abdulwahab H, Aljishi M, Sultan A, Al-Kafaji G, Sridharan K, Bakhiet M, Taha S, Whole blood transcriptomic analysis reveals PLSCR4 as a potential marker for vaso-occlusive crises in sickle cell disease., Sci Rep, 11(1), 22199, 2021 PubMed
Created on 2021-12-13 17:03:46, Last reviewed on (Show full history)

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