GeneID: 458
Names
Common Name: | miR-96 | Type: | Gene |
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Chromosome: | 7 (NC_000007.14) | Locus: | NG_023385.1 (MIR96) |
HUGO Symbol: | MIR96 | Full Name: | microRNA 96 |
Exons: | N/A | Introns: | N/A |
Description:
MicroRNAs (miRNAs), such as MIR96, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. Reporter gene assays demonstrated that MIR96 directly and sequence specifically targets the open reading frame (ORF) of the γ-globin mRNA, thereby inhibiting γ-globin expression. Additional evidence showed that MIR96 expression levels inversely correlated with increased HbF synthesis in erythroid cells of beta-thalassaemia patients and after hydroxyurea treatment in sickle cell anaemia patients. MIR96 acts as a negative regulator of γ-globin gene. Therapeutic approaches that increase the HbF concentration have great potential for ameliorating the clinical and haematologic severity of beta-thalassaemia and other beta-haemoglobinopathies.
Synonyms: DFNA50 , MIRN96 , miR-96 , miRNA96 , hsa-mir-96
Comments:
N/A
Number of entries/variants: 0
IthaScore
Publications / Origin
- Azzouzi I, Moest H, Winkler J, Fauchère JC, Gerber AP, Wollscheid B, Stoffel M, Schmugge M, Speer O, MicroRNA-96 directly inhibits γ-globin expression in human erythropoiesis., PLoS One, 6(7), e22838, 2011
- Eltaweel NH, ElKamah GY, Khairat R, Atia HAE, Amr KS, Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia., J Genet Eng Biotechnol, 19(1), 51, 2021
- Kargutkar N, Sawant-Mulay M, Hariharan P, Chandrakala S, Nadkarni A, Role of microRNA in hydroxyurea mediated HbF induction in sickle cell anaemia patients., Sci Rep, 13(1), 369, 2023
A/A | Date | Curator(s) | Comments |
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1 | 2021-09-22 14:54:45 | The IthaGenes Curation Team | Created |
2 | 2023-01-17 14:19:04 | The IthaGenes Curation Team | Reviewed. Reference added, Comment updated. |