GeneID: 452


Common Name: MIR214 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NR_029627.1 (MIR214)
HUGO Symbol: MIR214 Full Name: microRNA 214
Exons: 1 Introns: N/A

MicroRNAs (miRNAs), such as MIRN214, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression. MIRN214 maps to chromosome 1, where it lies within intron 14 of the DNM3 gene. Oxidative stress can regulate miRNA expression, which, in turn, can modulate cellular redox status by regulating reactive oxygen species (ROS) and antioxidant signaling. Oxidative stress in erythroid cells is a key driver of disease pathophysiology in haemoglobinopathies. Experiments showed an increase in miRNA214 expression in Hb H disease reticulocyte samples that correlated with ROS levels and anaemia severity, likely via suppression of ATF4 [GeneID: 379]. MIRN214 likely participates in oxidative pathways in erythroid cells that involve the ATF4 gene, a master transcription factor and regulator of γ-globin gene transcription.

Synonyms: N/A


Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Saensuwanna A, Penglong T, Srinoun K, Upregulation of miR-214 Mediates Oxidative Stress in Hb H Disease Targeting of ., Hemoglobin, 45(3), 197-202, 2021 PubMed
Created on 2021-08-31 16:12:53, Last reviewed on (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.