GeneID: 450
Names
| Common Name: | SOD1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 21 (NC_000021.9) | Locus: | NG_008689.1 (SOD1) |
| HUGO Symbol: | SOD1 | Full Name: | superoxide dismutase 1 |
| Exons: | 5 | Introns: | 4 |
Description:
The SOD1 gene encodes superoxide dismutase-1, a major cytoplasmic antioxidant enzyme that metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide, thus providing a defense against oxygen toxicity. Studies reported an up-regulation in gene and protein expression of SOD1 in β-thalassaemia intermedia patients compared to healthy individuals. This could result from compensatory mechanisms in response to the high levels of ROS observed in β-thalassaemia intermedia.
Synonyms: ALS , SOD , ALS1 , IPOA , STAHP , hSod1
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Zakaria NA, Islam MA, Abdullah WZ, Bahar R, Mohamed Yusoff AA, Abdul Wahab R, Shamsuddin S, Johan MF, Epigenetic Insights and Potential Modifiers as Therapeutic Targets in -Thalassemia., Biomolecules, 11(5), 0, 2021