GeneID: 442


Common Name: MAZ Type: Gene
Chromosome: 16 (NC_000016.10) Locus: NM_002383.4 (MAZ)
HUGO Symbol: MAZ Full Name: MYC associated zinc finger protein
Exons: 5 Introns: 4

The Myc-associated zinc finger protein (MAZ) was identified and characterized as a regulatory protein associated with MYC gene expression. It functions as a DNA-specific transcription factor and is often found at genomic binding sites adjacent to CTCF, the chromatin architectural factor. MAZ plays a role in erythropoiesis; it binds to the promoter of the alpha-globin genes and its shRNA-mediated knowckdown impairs differentiation in primary human erythroid cells. Genome-wide mapping in primary human erythroid cells revealed that MAZ also occupies active promoters as well as GATA1-bound enhancer elements of key genes within the erythroid differentiation pathway.

Synonyms: PUR1 , ZF87 , Pur-1 , SAF-1 , SAF-2 , SAF-3 , Zif87 , ZNF801 , ,


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Publications / Origin

  1. Xiao T, Li X, Felsenfeld G, The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization., Proc Natl Acad Sci U S A, 118(7), 0, 2021 PubMed
  2. Deen D, Butter F, Daniels DE, Ferrer-Vicens I, Ferguson DCJ, Holland ML, Samara V, Sloane-Stanley JA, Ayyub H, Mann M, Frayne J, Garrick D, Vernimmen D, Identification of the transcription factor MAZ as a regulator of erythropoiesis., Blood Adv, 5(15), 3002-3015, 2021 PubMed
Created on 2021-08-13 12:59:00, Last reviewed on (Show full history)

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