GeneID: 435



Names

Common Name: OR51B4 Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NM_033179.2 (OR51B4)
HUGO Symbol: OR51B4 Full Name: olfactory receptor family 51 subfamily B member 4
Exons: 1 Introns: N/A

Description:
Olfactory receptors (ORs) are members of a large family of G-protein-coupled receptors (GPCR) that transverse the membrane seven times and are located on the sensory neurons of nasal epithelium. The OR gene family is the largest in the genome and exists as clusters of genes in specific genomic locations. ORs bind to odorant molecules and transduce signals via a G protein, in turn activating downstream effector molecules that trigger the perception of smell. The olfactory system is highly discriminating and each OR can be activated by multiple odorants of similar structure. The ORs are grouped into subfamilies based on the type of odorant structure detected. OR51B4 encodes the olfactory receptor family 51 subfamily B member 4. The β-globin gene locus is surrounded by a large cluster of OR genes. Sequence variation in OR51B4 associated with disease severity in β-thalassaemia/HbE.

Synonyms: N/A

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Sherva R, Sripichai O, Abel K, Ma Q, Whitacre J, Angkachatchai V, Makarasara W, Winichagoon P, Svasti S, Fucharoen S, Braun A, Farrer LA, Genetic modifiers of Hb E/beta0 thalassemia identified by a two-stage genome-wide association study., BMC Med. Genet. , 11(0), 51, 2010 PubMed
Created on 2021-07-16 14:32:03, Last reviewed on (Show full history)


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