GeneID: 429


Common Name: ZNF410 Type: Gene
Chromosome: 14 (NC_000014.9) Locus: NM_021188.3 (ZNF410)
HUGO Symbol: ZNF410 Full Name: zinc finger protein 410
Exons: 12 Introns: 11

The encoded protein is a zinc finger protein involved in the regulation of γ-globin transcription. ZNF410 is widely expressed across human tissues. In erythroid cells, it specifically binds to two genome-wide unique and highly conserved motif clusters in the CHD4 locus. A series of experiments showed that ZNF410 interacts with the CHD4/NuRD component to repress γ-globin transcription in erythroid cells. Loss of ZNF410 can de-repress the γ-globin genes and lead to an increase in γ-globin transcription without affecting erythroid differentiation/maturation. ZNF410 is a candidate regulator of HbF expression and a potential target for HbF induction for β-haemoglobinopathies.

Synonyms: APA1 , APA-1


Publications / Origin

  1. Vinjamur DS, Yao Q, Cole MA, McGuckin C, Ren C, Zeng J, Hossain M, Luk K, Wolfe SA, Pinello L, Bauer DE, ZNF410 represses fetal globin by singular control of CHD4., Nat Genet, 2021
  2. Lan X, Ren R, Feng R, Ly LC, Lan Y, Zhang Z, Aboreden N, Qin K, Horton JR, Grevet JD, Mayuranathan T, Abdulmalik O, Keller CA, Giardine B, Hardison RC, Crossley M, Weiss MJ, Cheng X, Shi J, Blobel GA, ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression., Mol Cell, 81(2), 239-254.e8, 2021
Created on 2021-04-19 16:04:09, Last reviewed on (Show full history)

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