GeneID: 425
Names
Common Name: | LMO2 | Type: | Gene |
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Chromosome: | 11 (NC_000011.10) | Locus: | NM_005574.4 (LMO2) |
HUGO Symbol: | LMO2 | Full Name: | LIM domain only 2 |
Exons: | 6 | Introns: | 5 |
Description:
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. It interacts with GATA1, TAL1 and LDB1 to form a transcription factor complex that in turn binds to E-box/GATA motifs that are frequent in regulatory elements of erythroid-specific genes. This complex binds to both the locus control region (LCR) and globin gene promoters during erythroid differentiation.
Synonyms: TTG2 , LMO-2 , RBTN2 , RHOM2 , RBTNL1
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Iarovaia OV, Kovina AP, Petrova NV, Razin SV, Ioudinkova ES, Vassetzky YS, Ulianov SV, Genetic and Epigenetic Mechanisms of β-Globin Gene Switching., Biochemistry (Mosc), 83(4), 381-392, 2018
A/A | Date | Curator(s) | Comments |
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1 | 2021-02-03 14:50:59 | The IthaGenes Curation Team | Created |