GeneID: 424
Names
| Common Name: | ARRB1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 11 (NC_000011.10) | Locus: | NG_028118.1 (ARRB1) |
| HUGO Symbol: | ARRB1 | Full Name: | arrestin beta 1 |
| Exons: | 16 | Introns: | 15 |
Description:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. In addition, ARRB1 is implicated in the regulation of MAP kinase signaling pathways such as MAPK1/3 (ERK1/2) and p38 MAPK, which play a key role in the regulation of erythropoiesis. Ineffective erythropoiesis due to intramedullary apoptosis and delayed maturation of erythroid progenitor cells is the hallmark of beta-thalassaemia. Studies have shown significant changes in the expression of the ARRB1 gene in patients with beta-thalassaemia, thus implicating the ARRB1 gene in the pathogenesis of beta-thalassaemia, likely through the MAP kinase pathway.
Synonyms: ARB1 , ARR1
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Elghobashy YA, Assar MF, Mahmoud AA, Monem A Eltorgoman A, Elmasry S, The relation between mitogen activated protein kinase (MAPK) pathway and different genes expression in patients with beta Thalassemia., Biochem Biophys Rep, 24(0), 100836, 2020