GeneID: 423



Names

Common Name: DUSP5 Type: Gene
Chromosome: 10 (NC_000010.11) Locus: NM_004419.4 (DUSP5)
HUGO Symbol: DUSP5 Full Name: dual specificity phosphatase 5
Exons: 4 Introns: 3

Description:
The protein encoded by the DUSP5 gene is a member of the dual-specificity protein phosphatase (DUSP) family. These phosphatases are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues, thus inactivating their target kinases. DUSP5 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. The MAP kinase signaling pathway plays a key role in the regulation of erythropoiesis. Ineffective erythropoiesis due to intramedullary apoptosis and delayed maturation of erythroid progenitor cells is the hallmark of beta-thalassaemia. A significant change in the expression of the DUSP5 gene has been reported in patients with beta-thalassaemia, thus implicating DUSP5 in the pathogenesis of beta-thalassaemia, likely through the MAP kinase pathway.

Synonyms: DUSP , HVH3

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Elghobashy YA, Assar MF, Mahmoud AA, Monem A Eltorgoman A, Elmasry S, The relation between mitogen activated protein kinase (MAPK) pathway and different genes expression in patients with beta Thalassemia., Biochem Biophys Rep, 24(0), 100836, 2020 PubMed
Created on 2021-01-25 18:53:19, Last reviewed on 2021-01-25 18:55:05 (Show full history)


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