GeneID: 421


Names

Common Name: FGF23 Type: Gene
Chromosome: 12 (NC_000012.12) Locus: NG_007087.1 (FGF23)
HUGO Symbol: FGF23 Full Name: fibroblast growth factor 23
Exons: 3 Introns: 2

Description:
FGF23 encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. FGF23 acts as a negative regulator of bone metabolism and parathyroid hormone production. It is secreted as active intact protein (iFGF23) in bone and BM erythroid cells, and is inactivated by cleavage in c-terminal fragment (cFGF23). High levels of FGF23 were reported in beta-thalassemia patients with hypoparathyroidism. Erythropoietin (EPO) is an inducer of FGF23. Increased levels of EPO in β-thalassemia induce FGF23 overproduction in bone and BM erythroid cells via ERK1/2 and STAT5 pathways, negatively affecting bone and BM niche homeostasis. FGF23 serves as a candidate molecular link connecting anemia, bone, and the HSC niche in β-thalassemia.

Synonyms: ADHR , FGFN , HYPF , HFTC2 , HPDR2 , PHPTC

Comments:
N/A

Number of entries/variants: 0

IthaScore

Publications / Origin

  1. Saki F, Salehifar A, Kassaee SR, Omrani GR, Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study., BMC Nephrol, 21(1), 482, 2020
  2. Aprile A, Raggi L, Bolamperti S, Villa I, Storto M, Morello G, Marktel S, Tripodo C, Cappellini MD, Motta I, Rubinacci A, Ferrari G, Inhibition of FGF23 is a therapeutic strategy to target hematopoietic stem cell niche defects in β-thalassemia., Sci Transl Med, 15(698), eabq3679, 2023
Created on 2021-01-25 16:06:27, Last reviewed on 2024-01-22 15:22:08 (Show full history)


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