GeneID: 416


Common Name: HLA-G Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NG_029039.1 (HLA-G)
HUGO Symbol: HLA-G Full Name: major histocompatibility complex, class I, G
Exons: 8 Introns: 7

The HLA-G gene encodes a non-classical HLA class I molecule with important tolerogenic functions against innate and adaptive cellular responses. For example, the expression of HLA-G in pregnancy or allograft transplantation has been linked to a better acceptance of the fetus or the allograft. Variable HLA-G expression has been documented in several autoimmune diseases, viral infections, and cancer diseases. Genetic variance in HLA-G associated with cholelithiasis, or gallstones, in sickle cell disease.

Synonyms: MHC-G


Sequence Viewer

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Publications / Origin

  1. Baricordi OR, Stignani M, Melchiorri L, Rizzo R, HLA-G and inflammatory diseases., Inflamm Allergy Drug Targets, 7(2), 67-74, 2008 PubMed
  2. Tozatto-Maio K, Girot R, Ly ID, Silva Pinto AC, Rocha V, Fernandes F, Diagne I, Benzerara Y, Dinardo CL, Soler JP, Kashima S, Araujo IL, Kenzey C, Fonseca GHH, Rodrigues ES, Volt F, Jarduli L, Ruggeri A, Mariaselvam C, Gualandro SFM, Rafii H, Cappelli B, Nogueira FM, Scigliuolo GM, Guerino-Cunha RL, Malmegrim KCR, Simões BP, Gluckman E, Tamouza R, Polymorphisms in Inflammatory Genes Modulate Clinical Complications in Patients With Sickle Cell Disease., Front Immunol, 11(0), 2041, 2020 PubMed
Created on 2020-11-16 16:25:52, Last reviewed on (Show full history)

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