GeneID: 39

Names

Common Name:	TAL1	Type:	Gene
Chromosome:	1 (NC_000001.11)	Locus:	N/A
HUGO Symbol:	TAL1	Full Name:	T-cell acute lymphocytic leukemia 1
Exons:	5	Introns:	4

Description:
The gene encodes a basic helix-loop-helix transcription factor that binds to the E-box motif (CANNTG) of eukaryotic transcriptional enhancers. TAL1 is essential for normal hematopoiesis throughout development. Dysregulation of TAL1 activity in mice results in embryonic lethality due to severe anaemia. It is potentially involved in leukemogenesis since translocations associated with T-cell malignancies also deregulate its expression. The encoded protein interacts with erythroid-specific activators (such as GATA-1, LMO2 and LDB1) to mediate chromatin looping between the β-globin LCR (LCRB) and γ-globin (HBG) genes to activate their transcription.

Synonyms: SCL , TCL5 , tal-1 , bHLHa17

Comments:
N/A

Number of entries/variants: 0

External Links

NCBI Gene	UniProtKB
PDB	HGNC
OMIM

IthaScore

Publications / Origin

Pina C, Enver T, Differential contributions of haematopoietic stem cells to foetal and adult haematopoiesis: insights from functional analysis of transcriptional regulators., Oncogene , 26(47), 6750-65, 2007
Yun WJ, Kim YW, Kang Y, Lee J, Dean A, Kim A, The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription., Nucleic Acids Res. , 42(7), 4283-93, 2014

Created on , Last reviewed on 2016-04-25 14:12:29 (Show full history)

A/A	Date	Curator(s)	Comments
1		The IthaGenes Curation Team	Created
2	2016-04-25 10:40:10	The IthaGenes Curation Team	Reviewed.
3	2016-04-25 10:59:04	The IthaGenes Curation Team	Reviewed.
4	2016-04-25 11:24:17	The IthaGenes Curation Team	Reviewed.
5	2016-04-25 11:31:31	The IthaGenes Curation Team	Reviewed.
6	2016-04-25 11:34:54	The IthaGenes Curation Team	Reviewed.
7	2016-04-25 11:45:20	The IthaGenes Curation Team	Reviewed.
8	2016-04-25 11:45:40	The IthaGenes Curation Team	Reviewed.
9	2016-04-25 12:19:09	The IthaGenes Curation Team	Reviewed.
10	2016-04-25 12:20:00	The IthaGenes Curation Team	Reviewed.
11	2016-04-25 12:22:36	The IthaGenes Curation Team	Reviewed.
12	2016-04-25 12:29:01	The IthaGenes Curation Team	Reviewed.
13	2016-04-25 14:12:29	The IthaGenes Curation Team	Reviewed.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.