GeneID: 388

Names

Common Name:	JUN	Type:	Gene
Chromosome:	1 (NC_000001.11)	Locus:	NG_047027.1 (JUN)
HUGO Symbol:	JUN	Full Name:	Jun proto-oncogene, AP-1 transcription factor subunit
Exons:	1	Introns:	N/A

Description:
The oncogene JUN is the putative transforming gene of avian sarcoma virus 17; it appears to be derived from a gene of the chicken genome and has homologs in several other vertebrate species. A series of experiments demonstrated that JUN activates the Gγ-globin gene via binding to the upstream Gγ-globin gene cAMP response element (G-CRE) in a manner comparable to CREB [GeneID: 385] and ATF-2 [GeneID: 387]. JUN binds the G-CRE as a heterodimer with ATF-2 to modulate γ-globin expression.

Synonyms: AP1 , p39 , AP-1 , cJUN , c-Jun

Comments:
N/A

Number of entries/variants: 0

External Links

NCBI Gene	UniProtKB
PDB	HGNC
OMIM

IthaScore

Publications / Origin

Kodeboyina S, Balamurugan P, Liu L, Pace BS, cJun modulates Ggamma-globin gene expression via an upstream cAMP response element., Blood Cells Mol. Dis., 44(1), 7-15, 2010

Created on 2020-09-18 14:05:02, Last reviewed on (Show full history)

A/A	Date	Curator(s)	Comments
1	2020-09-18 14:05:02	The IthaGenes Curation Team	Created

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