GeneID: 387


Common Name: ATF2 Type: Gene
Chromosome: 2 (NC_000002.12) Locus: NG_047045.1 (ATF2)
HUGO Symbol: ATF2 Full Name: activating transcription factor 2
Exons: 14 Introns: 13

The ATF2 gene encodes a transcription factor that is a member of the basic leucine zipper (bZIP) family of DNA binding proteins. ATF2 requires phosphorylation or association with viral proteins for transcriptional activity. A series of experiments demonstrated that ATF2 binds the Gγ-globin gene cAMP response element (G-CRE) to modulate Gγ-globin expression, likely through p38 MAPK signaling and G-CRE trans-activation. It forms heterodimers with CREB1 [GeneID: 385] and JUN [GeneID: 388] in erythroid cells. It seems to have a regulatory role in various stages of erythropoiesis.

Synonyms: HB16 , CREB2 , TREB7 , CREB-2 , CRE-BP1


Sequence Viewer

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Publications / Origin

  1. Kodeboyina S, Balamurugan P, Liu L, Pace BS, cJun modulates Ggamma-globin gene expression via an upstream cAMP response element., Blood Cells Mol. Dis., 44(1), 7-15, 2010 PubMed
  2. Liu L, Karmakar S, Dhar R, Mahajan M, Choudhury A, Weissman S, Pace BS, Regulation of Gγ-globin gene by ATF2 and its associated proteins through the cAMP-response element., PLoS ONE, 8(11), e78253, 2013 PubMed
Created on 2020-09-18 14:00:43, Last reviewed on 2020-09-18 14:07:16 (Show full history)

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