GeneID: 387
Names
Common Name: | ATF2 | Type: | Gene |
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Chromosome: | 2 (NC_000002.12) | Locus: | NG_047045.1 (ATF2) |
HUGO Symbol: | ATF2 | Full Name: | activating transcription factor 2 |
Exons: | 14 | Introns: | 13 |
Description:
The ATF2 gene encodes a transcription factor that is a member of the basic leucine zipper (bZIP) family of DNA binding proteins. ATF2 requires phosphorylation or association with viral proteins for transcriptional activity. A series of experiments demonstrated that ATF2 binds the Gγ-globin gene cAMP response element (G-CRE) to modulate Gγ-globin expression, likely through p38 MAPK signaling and G-CRE trans-activation. It forms heterodimers with CREB1 [GeneID: 385] and JUN [GeneID: 388] in erythroid cells. It seems to have a regulatory role in various stages of erythropoiesis.
Synonyms: HB16 , CREB2 , TREB7 , CREB-2 , CRE-BP1
Comments:
N/A
Number of entries/variants: 0
Sequence Viewer
Publications / Origin
- Kodeboyina S, Balamurugan P, Liu L, Pace BS, cJun modulates Ggamma-globin gene expression via an upstream cAMP response element., Blood Cells Mol. Dis., 44(1), 7-15, 2010 PubMed
- Liu L, Karmakar S, Dhar R, Mahajan M, Choudhury A, Weissman S, Pace BS, Regulation of Gγ-globin gene by ATF2 and its associated proteins through the cAMP-response element., PLoS ONE, 8(11), e78253, 2013 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2020-09-18 14:00:43 | The IthaGenes Curation Team | Created |
2 | 2020-09-18 14:07:16 | The IthaGenes Curation Team | Reviewed. Reference added. |