GeneID: 386


Common Name: CREBBP Type: Gene
Chromosome: 16 (NC_000016.10) Locus: NG_009873.2 (CREBBP)
HUGO Symbol: CREBBP Full Name: CREB binding protein
Exons: 31 Introns: 30

The product of this gene functions as a transcriptional co-activator of various sequence-specific transcription factors with broad-spectrum cellular activities. The encoded protein has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. It contains a bromodomain that recognizes and binds to acetylated lysine residues on proteins. It was first identified as a factor binding to the cAMP response element-binding (CREB) protein [GeneID: 385], and only interacts with the PKA-phosphorylated form of the CREB protein. CREB and CBP co-localize to the upstream Gγ-globin cAMP-response element (G-CRE) located between -1222 and -1229 relative to the cap site to induce γ-globin expression. CBP is also crucial for erythroid differentiation as it directly binds to and activates transcription factors such as MYB, GATA1, NF-E2 and KLF.

Synonyms: CBP , RSTS , KAT3A , MKHK1 , RSTS1


Sequence Viewer

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Publications / Origin

  1. Dai P, Akimaru H, Tanaka Y, Hou DX, Yasukawa T, Kanei-Ishii C, Takahashi T, Ishii S, CBP as a transcriptional coactivator of c-Myb., Genes Dev., 10(5), 528-40, 1996 PubMed
  2. Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH, CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation., Proc. Natl. Acad. Sci. U.S.A., 95(5), 2061-6, 1998 PubMed
  3. Zhang W, Bieker JJ, Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases., Proc. Natl. Acad. Sci. U.S.A., 95(17), 9855-60, 1998 PubMed
  4. Ramakrishnan V, Pace BS, Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway., Blood Cells Mol. Dis., 47(1), 12-22, 2011 PubMed
Created on 2020-09-18 10:42:53, Last reviewed on (Show full history)

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