GeneID: 384
Names
| Common Name: | CYP2E1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 10 (NC_000010.11) | Locus: | NG_008383.1 (CYP2E1) |
| HUGO Symbol: | CYP2E1 | Full Name: | cytochrome P450 family 2 subfamily E member 1 |
| Exons: | 9 | Introns: | 8 |
Description:
The CYP2E1 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze the metabolism of exogenous compounds, including drugs, organic solvents and pro-carcinogens, as well as the oxidation of endogenous substrates such as steroids, fatty acids and other lipids. CYP2E1 is an inducible enzyme, and many of the substrates for CYP2E1 can induce their own metabolism. Many CYP2E1-catalyzed reactions can generate reactive oxygen species (ROS). Genetic variation at the CYP2E1 gene associated with production/accumulation of renal, hepatic and inflammation laboratory markers in sickle cell disease (SCD) patients treated with hydroxyurea.
Synonyms: CPE1 , CYP2E , P450-J , P450C2E
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Yahouédéhou SCMA, Carvalho MOS, Oliveira RM, Santiago RP, da Guarda CC, Carvalho SP, Ferreira JRD, Aleluia MM, Adorno EV, Gonçalves MS, Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters., Dis. Markers, 2018(0), 6105691, 2018