GeneID: 380


Common Name: CXCR2 Type: Gene
Chromosome: 2 (NC_000002.12) Locus: NG_052975.1 (CXCR2)
HUGO Symbol: CXCR2 Full Name: C-X-C motif chemokine receptor 2
Exons: 3 Introns: 2

The chemokine receptor CXCR2 is a member of the G-protein-coupled receptor family. It binds to several ligands including the potent chemoattractant interleukin-8, and transduces the signal through a G-protein activated second messenger system. It plays a key role in the recruitment and transmigration of neutrophils into inflamed tissues, a major mechanism of innate immunity. Bacterial infections are major complications in β-thalassaemia. There is evidence of reduced CXCR2 expression on the surface of neutrophils in β-thalassaemia/HbE patients, which may contribute to the impaired neutrophil migration seen in this cohort and to a subsequent increased susceptibility to infection.

Synonyms: CD182 , IL8R2 , IL8RA , IL8RB , CMKAR2 , CDw128b


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Publications / Origin

  1. Veenstra M, Ransohoff RM, Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?, J. Neuroimmunol., 246(1), 1-9, 2012 PubMed
  2. Thiengtavor C, Siriworadetkun S, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Vadolas J, Svasti S, Chaichompoo P, Increased ferritin levels in non-transfusion-dependent β°-thalassaemia/HbE are associated with reduced CXCR2 expression and neutrophil migration., Br. J. Haematol., 189(1), 187-198, 2020 PubMed
Created on 2020-06-25 17:35:12, Last reviewed on (Show full history)

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