GeneID: 380
Names
Common Name: | CXCR2 | Type: | Gene |
---|---|---|---|
Chromosome: | 2 (NC_000002.12) | Locus: | NG_052975.1 (CXCR2) |
HUGO Symbol: | CXCR2 | Full Name: | C-X-C motif chemokine receptor 2 |
Exons: | 3 | Introns: | 2 |
Description:
The chemokine receptor CXCR2 is a member of the G-protein-coupled receptor family. It binds to several ligands including the potent chemoattractant interleukin-8, and transduces the signal through a G-protein activated second messenger system. It plays a key role in the recruitment and transmigration of neutrophils into inflamed tissues, a major mechanism of innate immunity. Bacterial infections are major complications in β-thalassaemia. There is evidence of reduced CXCR2 expression on the surface of neutrophils in β-thalassaemia/HbE patients, which may contribute to the impaired neutrophil migration seen in this cohort and to a subsequent increased susceptibility to infection.
Synonyms: CD182 , IL8R2 , IL8RA , IL8RB , CMKAR2 , CDw128b
Comments:
N/A
Number of entries/variants: 0
IthaScore
Sequence Viewer
Publications / Origin
- Veenstra M, Ransohoff RM, Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?, J. Neuroimmunol., 246(1), 1-9, 2012 PubMed
- Thiengtavor C, Siriworadetkun S, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Vadolas J, Svasti S, Chaichompoo P, Increased ferritin levels in non-transfusion-dependent β°-thalassaemia/HbE are associated with reduced CXCR2 expression and neutrophil migration., Br. J. Haematol., 189(1), 187-198, 2020 PubMed
A/A | Date | Curator(s) | Comments |
---|---|---|---|
1 | 2020-06-25 17:35:12 | The IthaGenes Curation Team | Created |